Emam M. Esmayel
Internal Medicine and Biochemistry, Egypt
Title: Low plasma level of sirtuin-1 as a novel biomarkers of cerebrovascular stroke and its clinical severity
Biography
Biography: Emam M. Esmayel
Abstract
Background: Sirtuins are 7- members family of deacetylases that are involved in many metabolic and cellular processes in humans. Sirtuin-1 is well characterized for its anti-inflammatory and anti- oxidant properties. However, there is still controversy about its neuroprotective role. To our knowledge, this is the first study to assess plasma levels of sirtuin-1 in patients with stroke.
Objectives: This study is constructed with the objective of assessment whether plasma sirtuin-1 could discriminate between cases of stroke and controls and between ischemic and hemorrhagic stroke. Also, we aimed to assess the association between plasma sirtuin-1 level and clinical severity of stroke.
Methods: Plasma levels of sirtuin-1 were assessed in 14 patients with ischemic stroke and 13 patients with hemorrhagic stroke verified by CT brain imaging, as well as in 27 healthy control subjects matched for age, gender and body mass index by ELISA. Clinical severity of stroke was assessed by the modified National Institute of Health stroke scale ( mNIHSS) , where higher score denoted more severity.
Results: Plasma levels of sirtuin-1 were significantly lower in ischemic (1.49 ± 2.5 ng/ ml) and hemorrhagic( 1.48± 3.1ng /ml) groups , both compared to controls (4.35±5.4 ng/ml ,p= 0.02), with no significant difference between both stroke groups . Highly significant negative correlation was noticed between plasma sirtuin-1 levels and the score of mNIHSS(r=- 0.5, p=0.008) .
Conclusions: Low plasma sirtuin-1 might be a distinctive marker of cerebrovascular stroke and its clinical severity. However, it failed to discriminate between ischemic and hemorrhagic stroke. Further studies to assess its use in diagnosis, prevention and treatment of stroke are warranted.